1/7/2023 0 Comments Sovaldi side effect![]() Lab abnormalities such as elevations in bilirubin levels and lipase levels have been observed, and although not likely to be significant, should be monitored while undergoing treatment. Again, these are all considered mild to moderate, and very few people have to discontinue treatment because of them. In patients with decompensated cirrhosis, the above side effects can occur, with an addition of diarrhea. All of these side effects are considered to be mild. Less frequently reported side effects include nausea, insomnia, and asthenia (weakness). In patients without cirrhosis or in those with compensated cirrhosis, the most commonly reported side effects are headache and fatigue. Indeed, in the clinical trials for Epclusa, there were very few people-0.2%-who discontinued treatment due to side effects. What are the potential side effects and adverse events?Įpclusa is a very well-tolerated medication with minimal side effects. For more information, see HBV Reactivation for more information and consult your medical provider. Patients with HBV or some with past infection should be monitored during HCV DAA treatment, and some may need to take HBV treatment. HBV infection could get worse or reactivate again during or after DAA treatment, potentially leading to serious liver problems including liver failure or death. Never double your dose.īefore starting treatment with any DAA, including Epclusa, patients should take a blood test to check for hepatitis B (HBV) infection. Take your missed dose as soon as possible, unless it is closer to the time of your next dose. Ribavirin may be included in patients with decompensated cirrhosis. Take one tablet once daily with or without food. Sofosbuvir: Nucleotide analog NS5B polymerase inhibitorĪ fixed-dose combination sofosbuvir 400 mg/velpatasvir 100 mg.
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